Jan 28, 2012
             
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      Updated: Jan 28, 2012 
The impact of pharmacist-managed insulin titration program on achieving clinical goals in an underserved diabetic population   
A significant absolute difference in mean change in A1C at 6 months favoring pharmacist management.
Mortality associated with depressive disorders within 18 months of presentation of diabetic foot ulcers   
Significant association was shown by baseline DSM-IV depressive disorder with a twofold increased risk of mortality for any depressive episode, minor or major depressive disorders in the Cox regression by 246 depressed patients after adjusting for covariates as compared with patients who were not depressed.
Meta-analysis of the Danish Inter99 study: nominal association of minor alleles of COX10 rs9915302 and COX5B rs1466100 with type 2 diabetes   
None of alleles among the alleles potentially associated with type 2 diabetes influenced surrogate markers of insulin sensitivity negatively in non-diabetics while a weak negative influence on indices of glucose-stimulated insulin secretion was shown by the minor alleles of UQCRC1 rs2228561 and COX10 rs10521253.
Comparison of the incidence of subsequent vascular disease between treatment regimens by adding another oral glucose-lowering drug vs. starting insulin treatment   
After exclusions, 14, 904 people intensified treatment from one oral glucose-lowering drug, 7231 from two oral glucose-lowering drug and 978 from three oral glucose-lowering drug and started insulin (9, 41 and 90% respectively).
Significantly higher mean score on the Hypoglycemic Fear Survey-II in patients with hypoglycemic symptoms   
Significantly lower mean scores on the EQ-VAS and the EQ-5D were reported for patients who had hypoglycemic symptoms as compared to those who did not.
     
Affect of restrictive bariatric surgery on levels of vaspin in morbidly obese subjects   
Decreased levels of vaspin early after laparoscopic restrictive bariatric surgery is more likely due to decreased dietary intake
Insulin detemir in a twice daily insulin regimen versus a three times daily insulin regimen in children with type 1 diabetes   
Incorporating long acting insulin analogue in a twice daily regimen is a viable and more simplified option which may improve compliance in T1DM children.
Me-Can cohort study: An increased risk of high-grade glioma was found for diastolic blood pressure and triglycerides   
1312 primary brain tumours diagnosed during follow-up were predominantly meningioma (n=348) and high-grade glioma (n=436).
The PARTAGE study: prevalence of orthostatic hypotension and its association with blood pressure, arterial stiffness, cardiovascular and metabolic disorders and medication in individuals aged > 80 years living in nursing home   
A lower prevalence of orthostatic hypotension was reported in treated hypertensive patients with SBP ≤ 140 mmHg than patients with SBP > 140 mmHg.
Higher serum sclerostin levels in type 2 diabetics specifically contributes to the detrimental effect of thiazolidinediones on bone   
Serum sclerostin levels increased by 11% in pioglitazone -treated patients after 24 weeks treatment and decreased by 1.8% in metformin -treated patients
Besides gestational age the most significant predictor of infant birth weight is maternal weight at screening   
Maternal birth weight, BMI at 20 years of age and maximal BMI correlated significantly with newborn birth weight, newborn length and with infant weight eight weeks later in all women.
Affect of lifestyle interventions on dyslipidemia in women of reproductive age   
Most guidelines recommended dyslipidemia screening every 5 years
Metabolic substudy of ANRS COPANA cohort: severe immune deficiency in antiretroviral therapy -naive patients as an early risk factor for altered insulin sensitivity   
Low CD4 (+) T-cell count was an independent risk factor for altered insulin sensitivity (CD4 (+) T-cell count >500/mm³ as the reference) in addition to older age and higher BMI.
Association of accuracy of duplex scanning with arteriography when performed at vascular "dedicated" or "nondedicated" facilities, among diabetic patients with critical limb ischemia   
significantly higher diagnostic accuracy pertaining to the examination of the infrapopliteal arteries was observed in diabetic patients with duplex scanning
Twice daily versus multiple daily insulin injections in children with type 1 diabetes   
Children started on MDI show better mean improvement in HbA1c at 12 months than started on started on BD insulin
Risk of hypoglycemia in critically ill children may increase by the disruptions in carbohydrate metabolism   
Best accomplishment of the prevention of hypoglycemia, especially in the setting of intravenous insulin use is achieved by the combination of accurate measuring techniques, frequent or continuous glucose monitoring, and computerized insulin titration protocols
ADDITION study (Anglo-Danish-Dutch Study of Intensive Treatment in People with Screen Detected Diabetes in Primary Care): correlation between heart rate and heart rate variability measurements by the computer-assisted and manually based methods   
Correlation, r values of Pearson's obtained on comparing results from the two methods: 0.98 for heart rate, 0.76 for SDNN and 0.68 for RMSSD.
Breath-based lipid test study reveals strong correlations between measured and predicted values during both lipid suppression and lipid infusion studies   
Measured and predicted triglycerides and free fatty acids values also displayed very strong statistical agreement in this most accurate common prediction model.
Major display of a triad of recent onset diabetes with significant weight loss and jaundice or dilated common bile duct without any obvious cause in pancreatic cancer patients   
124/167 pancreatic cancer patients displayed recent onset diabetes (<1yr), all of whom were non obese and either had jaundice or a dilated v without any other cause apart from abdominal symptoms
Hyperglycemic clamp study: Inverse relationship between insulinemia and time to maximum perfusion during post occlusive reactive hyperemia in type 1 diabetics   
Higher maximum perfusion and higher velocity of perfusion increase during PORH were reported in hyperglycemia compared to baseline.
Affect of baseline Hemoglobin A1C on efficacy of Liraglutide and other anthiyperglycemic therapies   
Reductions in A1C levels are generally greater in groups with higher baseline A1C values irrespective of treatment
Italian Diabetes and Exercise Study (IDES): Exercise volume, study arm and inversely baseline score were the independent correlates of improvements in both physical component summary and mental component summary   
A trend for increasing quality of life with increasing exercise volume with significant improvement of the physical component summary measure only above 17.5 metabolic equivalents h -1 week -1 and a clear volume-relationship were reported for the mental component summary measure in the exercise group.
The PREdiction of Metabolic Syndrome in Adolescence (PREMA) Study: prediction of MetS among adolescents of the validation cohort with sensitivity 91% and specificity 98%   
105 adolescents in the derivation phase were diagnosed with MetS, whereas diagnosis of MetS in adolescence was independently associated with birth weight <10th percentile, birth head circumference <10th percentile and parental overweight or obesity (at least in one parent).
Significantly greater walking palmitate storage in lower-body subcutaneous fat among women   
Similar upper body subcutaneous palmitate storage was reported during walking between sexes, while greater lower-body subcutaneous storage was reported in women than men.
Diabetic retinopathy doubles the frequency of blindness   
Twice as frequent prevalence of blindness was reported in patients with diabetic retinopathy when compared to those without it.
A simple, brief integrated approach to depression and type 2 diabetes treatment improves adherence to oral hypoglycemic agents and antidepressant medications, glycemic control and depression among primary care patients   
More likely to achieve HbA 1c levels of < 7% and remission of depression (PHQ-9 score of < 5) was reported in patients who received the intervention as compared to patients in the usual care group at 12 weeks
High prevalence of pre-diabetes in adults treated with antipsychotic drugs   
Highly prevalent pre-diabetes is reported in adults treated with antipsychotic drugs which correlate with markers of increased intra-abdominal adiposity, enhanced lipolysis and insulin resistance.
Effects of short-term administration of liraglutide on visceral fat adiposity, appetite, and food preference   
Liraglutide significantly improves the scores of eating behavior, food preference and the urge for fat intake
Extremely obese children and adolescents at high risk of future weight gain and potentially reduced response to weight-loss interventions   
Significantly higher levels of leptin were reported by extremely obese than obese, overweight and normal weight.
Noninsulin treatment of type 2 diabetes mellitus geriatric patients   
Prevalence of hypoglycemia is high with the administration of secretagogues, sulfonylureas and glinides
Renal biopsy should be considered in type 2 diabetics with nephropathy   
Presence of acute renal failure and microscopic hematuria are the useful clinical markers for non-diabetic renal diseases.
Homocysteine and bilirubin may be useful biomarkers for increased risk of diabetic retinopathy   
Incidence of diabetic retinopathy was statistically and significantly associated with the duration of DM, age, fasting blood glucose, urine albumin-creatinine ratio, plasma homocysteine level, duration of DM and total bilirubin level in multiple logistic regression analysis.
Higher self-rating depression scale and higher Pittsburgh sleep quality index in diabetics   
Higher Pittsburgh Sleep Quality Index was reported in diabetic patients with neuropathy and higher Self-Rating Depression Scale was reported in diabetic patients with advanced retinopathy.
Collaborative, team-based and care management program for complex patients (TEAMcare):   
Pharmacotherapy initiation and adjustment rates were sixfold higher for antidepressants, threefold higher for insulin and nearly twofold higher for antihypertensive medications among TEAMcare as compared to usual care patients.
Higher prevalence of diabetes among people with a lifetime diagnosis of schizophrenia or psychosis   
A clear increase in the probability of having diabetes was reported as the number of psychotic symptoms increased after controlling for different potential confounders.
Glycemic control improvement by the addition of metformin to insulin therapy shortly after resolution of diabetic ketoacidosis in obese children with diabetic ketoacidosis   
Lower HbA1c levels, higher rates of near-normoglycemia remission and lower frequency of diabetic ketoacidosis recurrence were observed by the addition of metformin to insulin therapy shortly after resolution of diabetic ketoacidosis.
DIAB-CORE Consortium: higher prevalence of type 2 diabetes in men than in women and highest regional standardized prevalence in the East Germany   
Among persons with Type 2 diabetes, more frequent treatment with oral antidiabetic agents was reported in the south and less in the northeast, whereas more frequent treatment with insulin alone was reported in the northeast than in the south.
Additional benefit of flavonoids to standard drug therapy in managing CVD risk in postmenopausal type 2 diabetic patients   
The combined flavonoid intervention resulted in a significant reduction in estimated peripheral insulin resistance and improvement in insulin sensitivity.
Effect of statins on exercise-induced muscle injury   
Susceptibility to exercise-induced muscle injury with statins increases with age
Factors influencing health-related quality of life in patients with and without diabetic foot ulcers   
Among diabetic patients without foot ulcers, male gender score higher in all domains of quality of life than female gender
Global Battle of the Sweetened Heart continues...  
Current studies on Diabetes control and renal function  
Which One Has Higher Effectiveness Index - SGLT2 Inhibitors or DPP4 Inhibitors?  
Continuous Glucose Monitoring Improves glycemic control in Diabetic Patients  
Glycemic Control and Risk Factors for Hospitalization  
  More..     
 

     

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FDA wields the whip on Gastric Banding Centers    
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ADA 2012 - 72nd Scientific Sessions
Jun 8, 2012 - Jun 12, 2012.
Philadelphia, Pennsylvania


    

 


 


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